CHENG Laboratory Epigenetics and Therapeutics in Immuno-Oncology

Publications

Highlights

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Zhewen Xiong, Stephen Lam Chan, Jingying Zhou, Joaquim S.L. Vong, Tsz Tung Kwong, ..., Ka-Fai To, Kevin Yuk-Lap Yip, Yuk Ming Dennis Lo, Joseph Jao-Yiu Sung, Alfred Sze-Lok Cheng
Gut   ·   05 Apr 2023   ·   doi:10.1136/gutjnl-2022-328364
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, ..., Chung Hang Jonathan Choi, Joseph Jao-yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-lok Cheng
Molecular Therapy   ·   04 Jan 2023   ·   doi:10.1016/j.ymthe.2022.09.012
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Haoran Wu, ..., Simon K. H. Wong, Vincent W. S. Wong, Alice P. S. Kong, Joseph J. Y. Sung, Alfred S. L. Cheng
Cellular & Molecular Immunology   ·   20 May 2022   ·   doi:10.1038/s41423-022-00872-3
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
Weiqin Yang, Yu Feng, Jingying Zhou, Otto Ka-Wing Cheung, Jianquan Cao, ..., Zhiwei Chen, Joseph Jao-Yiu Sung, Kevin Yuk-Lap Yip, Ka-Fai To, Alfred Sze-Lok Cheng
Science Translational Medicine   ·   07 Apr 2021   ·   doi:10.1126/scitranslmed.aaz6804
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis
Xuezhen Zeng, Jingying Zhou, Zhewen Xiong, Hanyong Sun, Weiqin Yang, ..., Jun Yu, Sui Peng, Joseph Jao-Yiu Sung, Ming Kuang, Alfred Sze-Lok Cheng
Cellular & Molecular Immunology   ·   02 Sep 2020   ·   doi:10.1038/s41423-020-00534-2
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
Man Liu, Jingying Zhou, Xiaoyu Liu, Yu Feng, Weiqin Yang, ..., Anthony W H Chan, Ka Fai To, Joseph J Y Sung, Minhu Chen, Alfred Sze-Lok Cheng
Gut   ·   07 Jan 2020   ·   doi:10.1136/gutjnl-2018-317257
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Yuan Tian, Bin Yang, Weinan Qiu, Yajing Hao, Zhenxing Zhang, ..., Joseph J. Y. Sung, Runsheng Chen, Hong-Yang Wang, Alfred S. L. Cheng, Pengyuan Yang
Nature Communications   ·   29 Jul 2019   ·   doi:10.1038/s41467-019-11274-x
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Lei Xiong, Feng Wu, Qiong Wu, Liangliang Xu, Otto K. Cheung, ..., Michael W. Chan, Tim H. Huang, Kevin Y. Yip, Alfred S. Cheng, Ka-Fai To
Nature Communications   ·   18 Jan 2019   ·   doi:10.1038/s41467-018-08245-z
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, ..., Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong, Alfred S. L. Cheng
Nature Communications   ·   06 Dec 2018   ·   doi:10.1038/s41467-018-07402-8
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
Jingying Zhou, Man Liu, Hanyong Sun, Yu Feng, Liangliang Xu, ..., Zhiwei Chen, Joseph JY Sung, King Lau Chow, Ka Fai To, Alfred Sze-Lok Cheng
Gut   ·   22 Sep 2017   ·   doi:10.1136/gutjnl-2017-314032

All Publications

2023

Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis
Jingying Zhou, Huanyu Wang, Ting Shu, Jing Wang, Weiqin Yang, ..., Shun-Wa Tsang, Simon E. Ward, King-Lau Chow, Joseph Jao-yiu Sung, Alfred Sze-Lok Cheng
iScience   ·   01 Oct 2023   ·   doi:10.1016/j.isci.2023.107626
The E2F1–HOXB9/PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer
Jinglin Zhang, Bonan Chen, Yifei Wang, Xiaoli Liu, Huan Yan, ..., Alfred SL Cheng, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang
The Journal of Pathology   ·   05 Jun 2023   ·   doi:10.1002/path.6091
Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models
Stanley K. K. Cheung, Jacinda Kwok, Penelope M. Y. Or, Chi Wai Wong, Bo Feng, Kwong Wai Choy, Raymond C. C. Chang, J. Peter H. Burbach, Alfred S. L. Cheng, Andrew M. Chan
Scientific Reports   ·   25 Apr 2023   ·   doi:10.1038/s41598-023-33869-7
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Zhewen Xiong, Stephen Lam Chan, Jingying Zhou, Joaquim S.L. Vong, Tsz Tung Kwong, ..., Ka-Fai To, Kevin Yuk-Lap Yip, Yuk Ming Dennis Lo, Joseph Jao-Yiu Sung, Alfred Sze-Lok Cheng
Gut   ·   05 Apr 2023   ·   doi:10.1136/gutjnl-2022-328364
Compromised browning in white adipose tissue of ageing people
Ping Gu, Kai Ding, Lei Lu, Yu Zhang, Wei Wang, ..., Bin Lu, Alice P S Kong, Alfred S Cheng, Hannah Xiaoyan Hui, Jiaqing Shao
European Journal of Endocrinology   ·   08 Feb 2023   ·   doi:10.1093/ejendo/lvad014
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, ..., Chung Hang Jonathan Choi, Joseph Jao-yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-lok Cheng
Molecular Therapy   ·   04 Jan 2023   ·   doi:10.1016/j.ymthe.2022.09.012
Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing
Qing Liu, Qiaoyun Long, Jiayu Zhao, Wenjie Wu, Zexin Lin, ..., Donghai Wu, Alice P. S. Kong, Jingying Zhou, Alfred S. Cheng, Hannah Xiaoyan Hui
Research   ·   01 Jan 2023   ·   doi:10.34133/research.0182

2022

Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2IGF1R and Hippo–YAP1 signaling pathways
Jinglin Zhang, Bonan Chen, Hui Li, Yifei Wang, Xiaoli Liu, ..., Alfred SL Cheng, Brigette BY Ma, Jun Yu, Kwok Wai Lo, Wei Kang
The Journal of Pathology   ·   17 Dec 2022   ·   doi:10.1002/path.6033
Meltdown of the cold tumour microenvironment: a new ‘translational’ approach to augment immunotherapy efficacy
Alfred Sze-Lok Cheng
Gut   ·   13 Dec 2022   ·   doi:10.1136/gutjnl-2022-328861
Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties
Ping Sun, Jing Wang, Khadija S. Khan, Weiqin Yang, Billy Wai-Lung Ng, ..., Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred Sze-Lok Cheng, Wolfgang Sippl
Journal of Medicinal Chemistry   ·   30 Nov 2022   ·   doi:10.1021/acs.jmedchem.2c01132
Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients
Zhiwu Tan, Mei Sum Chiu, Xinxiang Yang, Ming Yue, Tan To Cheung, ..., Stephen Lam Chan, Li Liu, You-Qiang Song, Kwan Man, Zhiwei Chen
Gut   ·   30 Nov 2022   ·   doi:10.1136/gutjnl-2022-327133
The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma
Tian Liu, Yubing Wang, Yiwei Wang, Stanley Kwok-Kuen Cheung, Penelope Mei-Yu Or, ..., Wayne Lut-Heng Ho, Haiwei Gu, Alfred Sze-Lok Cheng, Stephen Kwok-Wing Tsui, Andrew M. Chan
Cancer Letters   ·   01 Nov 2022   ·   doi:10.1016/j.canlet.2022.215914
Eliminating METTL1‐mediated accumulation of PMN‐MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation
Xuezhen Zeng, Guanrui Liao, Shumin Li, Haining Liu, Xiao Zhao, ..., Sui Peng, Shuibin Lin, Ji Wang, Shuling Chen, Ming Kuang
Hepatology   ·   08 Jul 2022   ·   doi:10.1002/hep.32585
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Haoran Wu, ..., Simon K. H. Wong, Vincent W. S. Wong, Alice P. S. Kong, Joseph J. Y. Sung, Alfred S. L. Cheng
Cellular & Molecular Immunology   ·   20 May 2022   ·   doi:10.1038/s41423-022-00872-3
Vitamin D3and carbamazepine protect againstClostridioides difficileinfection in mice by restoring macrophage lysosome acidification
Hung Chan, Qing Li, Xiansong Wang, Wing Yingzhi Liu, Wei Hu, ..., Alfred Sze Lok Cheng, Lin Zhang, Matthew Tak Vai Chan, Sunny Hei Wong, William Ka Kei Wu
Autophagy   ·   06 Jan 2022   ·   doi:10.1080/15548627.2021.2016004
Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis
Feng Wu, Liangliang Xu, Yalin Tu, Otto KW. Cheung, Lemuel LM. Szeto, ..., Patrick Tan, Joseph JY. Sung, Kevin Y. Yip, Alfred SL. Cheng, Ka F. To
Cancer Letters   ·   01 Jan 2022   ·   doi:10.1016/j.canlet.2021.10.039
MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target
Yifei Wang, Huarong Chen, Weixin Liu, Huan Yan, Yihan Zhang, ..., Brigette B.Y. Ma, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang
Theranostics   ·   01 Jan 2022   ·   doi:10.7150/thno.75431

2021

Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition
Philip Chiu‐Tsun Tang, Jeff Yat‐Fai Chung, Vivian Wei‐wen Xue, Jun Xiao, Xiao‐Ming Meng, ..., Kam‐Tong Leung, Eric W.‐F. Lam, Ka‐Fai To, Patrick Ming‐Kuen Tang, Hui‐Yao Lan
Advanced Science   ·   17 Nov 2021   ·   doi:10.1002/advs.202101235
Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives
Xuezhen Zeng, Simon E. Ward, Jingying Zhou, Alfred S. L. Cheng
Cancers   ·   17 May 2021   ·   doi:10.3390/cancers13102418
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
Weiqin Yang, Yu Feng, Jingying Zhou, Otto Ka-Wing Cheung, Jianquan Cao, ..., Zhiwei Chen, Joseph Jao-Yiu Sung, Kevin Yuk-Lap Yip, Ka-Fai To, Alfred Sze-Lok Cheng
Science Translational Medicine   ·   07 Apr 2021   ·   doi:10.1126/scitranslmed.aaz6804
Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade
Tsz Tung Kwong, Chi Hang Wong, Jing Ying Zhou, Alfred Sze Lok Cheng, Joseph Jao Yiu Sung, Anthony Wing Hung Chan, Stephen Lam Chan
JHEP Reports   ·   01 Apr 2021   ·   doi:10.1016/j.jhepr.2020.100224
Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance
Dan Huang, Xiansong Wang, Yingzhi Liu, Ziheng Huang, Xiaoxu Hu, ..., Jianxiong Shen, Lin Zhang, Matthew T V Chan, Xiaodong Liu, William K K Wu
Briefings in Bioinformatics   ·   30 Mar 2021   ·   doi:10.1093/bib/bbab040
A proof-of-concept study for the pathogenetic role of enhancer hypomethylation of MYBPHL in multiple myeloma
Kwan Yeung Wong, Gareth J. Morgan, Eileen M. Boyle, Alfred Sze Lok Cheng, Kevin Yuk-Lap Yip, Chor Sang Chim
Scientific Reports   ·   26 Mar 2021   ·   doi:10.1038/s41598-021-86473-y
NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway
Wei Kang, Jinglin Zhang, Tingting Huang, Yuhang Zhou, Chi Chun Wong, ..., Alfred S. L. Cheng, Jun Yu, Nathalie Wong, Kwok Wai Lo, Ka Fai To
Oncogene   ·   15 Jan 2021   ·   doi:10.1038/s41388-020-01579-3

2020

MCM family in gastrointestinal cancer and other malignancies: From functional characterization to clinical implication
Yifei Wang, Huarong Chen, Jinglin Zhang, Alfred S.L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer   ·   01 Dec 2020   ·   doi:10.1016/j.bbcan.2020.188415
The Intersection between Oral Microbiota, Host Gene Methylation and Patient Outcomes in Head and Neck Squamous Cell Carcinoma
Zigui Chen, Po Yee Wong, Cherrie W. K. Ng, Linlin Lan, Sherwood Fung, ..., Eddy W. Y. Wong, Alfred S. L. Cheng, Jun Yu, Paul K. S. Chan, Jason Y. K. Chan
Cancers   ·   18 Nov 2020   ·   doi:10.3390/cancers12113425
FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential
Jinglin Zhang, Chi Chun Wong, Kam Tong Leung, Feng Wu, Yuhang Zhou, ..., Jun Yu, Nathalie Wong, Kwok Wai Lo, Ka Fai To, Wei Kang
Oncogene   ·   15 Sep 2020   ·   doi:10.1038/s41388-020-01458-x
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis
Xuezhen Zeng, Jingying Zhou, Zhewen Xiong, Hanyong Sun, Weiqin Yang, ..., Jun Yu, Sui Peng, Joseph Jao-Yiu Sung, Ming Kuang, Alfred Sze-Lok Cheng
Cellular & Molecular Immunology   ·   02 Sep 2020   ·   doi:10.1038/s41423-020-00534-2
A unified framework for integrative study of heterogeneous gene regulatory mechanisms
Qin Cao, Zhenghao Zhang, Alexander Xi Fu, Qiong Wu, Tin-Lap Lee, Eric Lo, Alfred S. L. Cheng, Chao Cheng, Danny Leung, Kevin Y. Yip
Nature Machine Intelligence   ·   27 Jul 2020   ·   doi:10.1038/s42256-020-0205-2
Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation
Zhuo Yu, Hai Feng, Yunhui Zhuo, Man Li, Xiaojun Zhu, ..., Fan Le, Dae-Yeul Yu, Alfred Szelok Cheng, Xuehua Sun, Yueqiu Gao
Cellular Oncology   ·   04 Jul 2020   ·   doi:10.1007/s13402-020-00546-0
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis
Yuhang Zhou, Jinglin Zhang, Hui Li, Tingting Huang, Chi Chun Wong, ..., Nathalie Wong, Kwok Wai Lo, Patrick M. K. Tang, Wei Kang, Ka Fai To
Oncogene   ·   20 Apr 2020   ·   doi:10.1038/s41388-020-1293-5
Autism‐associated PTEN missense mutation leads to enhanced nuclear localization and neurite outgrowth in an induced pluripotent stem cell line
Chi Wai Wong, Yubing Wang, Tian Liu, Lisha Li, Stanley Kwok Kuen Cheung, ..., Kwong Wai Choy, Johannes Peter Henri Burbach, Bo Feng, Raymond Chuen Chung Chang, Andrew M. Chan
The FEBS Journal   ·   26 Mar 2020   ·   doi:10.1111/febs.15287
Gastric cancer: genome damaged by bugs
Yanan Zhao, Jinglin Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Oncogene   ·   02 Mar 2020   ·   doi:10.1038/s41388-020-1241-4
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
Man Liu, Jingying Zhou, Xiaoyu Liu, Yu Feng, Weiqin Yang, ..., Anthony W H Chan, Ka Fai To, Joseph J Y Sung, Minhu Chen, Alfred Sze-Lok Cheng
Gut   ·   07 Jan 2020   ·   doi:10.1136/gutjnl-2018-317257

2019

ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Yuan Tian, Bin Yang, Weinan Qiu, Yajing Hao, Zhenxing Zhang, ..., Joseph J. Y. Sung, Runsheng Chen, Hong-Yang Wang, Alfred S. L. Cheng, Pengyuan Yang
Nature Communications   ·   29 Jul 2019   ·   doi:10.1038/s41467-019-11274-x
Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis
Jinglin Zhang, Patrick M. K. Tang, Yuhang Zhou, Alfred S. L. Cheng, Jun Yu, Wei Kang, Ka Fai To
Cells   ·   25 Jun 2019   ·   doi:10.3390/cells8060637
Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis
Jinglin Zhang, Yuhang Zhou, Patrick Tang, Alfred Cheng, Jun Yu, Ka To, Wei Kang
International Journal of Molecular Sciences   ·   29 Mar 2019   ·   doi:10.3390/ijms20071576
New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation
Le Li, Yuwei Gao, Qiong Wu, Alfred S.L. Cheng, Kevin Y. Yip
Genome Research   ·   19 Feb 2019   ·   doi:10.1101/gr.240036.118
E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness
Frank H. C. Cheng, Hon‐Yi Lin, Tzy‐Wei Hwang, Yin‐Chen Chen, Rui‐Lan Huang, ..., Alfred S. L. Cheng, Hung‐Cheng Lai, Shu‐Fen Wu, Je‐Chiang Tsai, Michael W. Y. Chan
Cancer Science   ·   25 Jan 2019   ·   doi:10.1111/cas.13920
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Lei Xiong, Feng Wu, Qiong Wu, Liangliang Xu, Otto K. Cheung, ..., Michael W. Chan, Tim H. Huang, Kevin Y. Yip, Alfred S. Cheng, Ka-Fai To
Nature Communications   ·   18 Jan 2019   ·   doi:10.1038/s41467-018-08245-z

2018

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, ..., Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong, Alfred S. L. Cheng
Nature Communications   ·   06 Dec 2018   ·   doi:10.1038/s41467-018-07402-8
Targeting the miR-630/YAP1/ERK feedback loop in epidermal growth factor receptor-mutated lung adenocarcinomas
Jinglin Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Journal of Thoracic Disease   ·   01 Nov 2018   ·   doi:10.21037/jtd.2018.10.16
Oncogenes expand during evolution to withstand somatic amplification
X. Wang, X. Li, L. Zhang, S.H. Wong, M.H.T. Wang, ..., J.J.Y. Sung, J. Yu, T. Gin, M.T.V. Chan, W.K.K. Wu
Annals of Oncology   ·   01 Nov 2018   ·   doi:10.1093/annonc/mdy397
Androgen receptor drives hepatocellular carcinogenesis by activating enhancer of zeste homolog 2-mediated Wnt/β-catenin signaling
Haibin Song, Zhuo Yu, Xuehua Sun, Jun Feng, Qi Yu, ..., Man Li, Myth T.S. Mok, Alfred S.L. Cheng, Yueqiu Gao, Hai Feng
EBioMedicine   ·   01 Sep 2018   ·   doi:10.1016/j.ebiom.2018.08.043
FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p
Jinglin Zhang, Yuhang Zhou, Tingting Huang, Feng Wu, Yi Pan, ..., Alfred S. L. Cheng, Jun Yu, Kwok Wai Lo, Wei Kang, Ka Fai To
Oncogene   ·   06 Aug 2018   ·   doi:10.1038/s41388-018-0430-x
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis
Ying-Ying Lee, Myth TS Mok, Wei Kang, Weiqin Yang, Wenshu Tang, ..., Grace L H Wong, Andrew M Chan, Kevin Y Yip, Ka-Fai To, Alfred S L Cheng
Nucleic Acids Research   ·   10 Jul 2018   ·   doi:10.1093/nar/gky589
Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
Yuhang Zhou, Tingting Huang, Jinglin Zhang, Alfred S.L. Cheng, Jun Yu, Wei Kang, Ka Fai To
Cancer Letters   ·   01 Jul 2018   ·   doi:10.1016/j.canlet.2018.04.004
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Myth T. Mok, Jingying Zhou, Wenshu Tang, Xuezhen Zeng, Antony W. Oliver, Simon E. Ward, Alfred S. Cheng
Pharmacology & Therapeutics   ·   01 Jun 2018   ·   doi:10.1016/j.pharmthera.2018.01.008
PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis
Jinglin Zhang, Yuhang Zhou, Tingting Huang, Feng Wu, Liping Liu, Johnny S. H. Kwan, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Molecular Carcinogenesis   ·   02 May 2018   ·   doi:10.1002/mc.22831
The physiological role of Motin family and its dysregulation in tumorigenesis
Tingting Huang, Yuhang Zhou, Jinglin Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Journal of Translational Medicine   ·   12 Apr 2018   ·   doi:10.1186/s12967-018-1466-y
Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase
Zhuo Yu, Hai Feng, Xuehua Sun, Yunhui Zhuo, Man Li, ..., Xin Zhang, Fan Le, Chao Zheng, Alfred Szelok Cheng, Yueqiu Gao
Scientific Reports   ·   01 Mar 2018   ·   doi:10.1038/s41598-018-22113-2
miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis
Wei Kang, Tingting Huang, Yuhang Zhou, Jinglin Zhang, Raymond W. M. Lung, ..., Alvin H. K. Cheung, Jesse C. S. Pang, Jun Yu, Alfred S. L. Cheng, Ka Fai To
Cell Death & Disease   ·   24 Jan 2018   ·   doi:10.1038/s41419-017-0134-0

2017

SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis
Tingting Huang, Yuhang Zhou, Jinglin Zhang, Chi Chun Wong, Weilin Li, ..., Alfred S. L. Cheng, Jun Yu, Nathalie Wong, Wei Kang, Ka Fai To
Oncogene   ·   13 Dec 2017   ·   doi:10.1038/s41388-017-0029-7
The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma
Bin Zhang, Yajing Zhang, Xiaoping Zou, Anthony WH Chan, Rui Zhang, ..., Vincent W Keng, Larry MC Chow, Kenrick KY Chan, Alfred S Cheng, Ben CB Ko
The Journal of Pathology   ·   27 Oct 2017   ·   doi:10.1002/path.4976
The oncogenic role of Epstein–Barr virus‐encoded microRNAs in Epstein–Barr virus‐associated gastric carcinoma
Jinglin Zhang, Tingting Huang, Yuhang Zhou, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Journal of Cellular and Molecular Medicine   ·   09 Oct 2017   ·   doi:10.1111/jcmm.13354
START: a system for flexible analysis of hundreds of genomic signal tracks in few lines of SQL-like queries
Xinjie Zhu, Qiang Zhang, Eric Dun Ho, Ken Hung-On Yu, Chris Liu, Tim H. Huang, Alfred Sze-Lok Cheng, Ben Kao, Eric Lo, Kevin Y. Yip
BMC Genomics   ·   22 Sep 2017   ·   doi:10.1186/s12864-017-4071-1
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
Jingying Zhou, Man Liu, Hanyong Sun, Yu Feng, Liangliang Xu, ..., Zhiwei Chen, Joseph JY Sung, King Lau Chow, Ka Fai To, Alfred Sze-Lok Cheng
Gut   ·   22 Sep 2017   ·   doi:10.1136/gutjnl-2017-314032
Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines
Qin Cao, Christine Anyansi, Xihao Hu, Liangliang Xu, Lei Xiong, ..., Chao Cheng, Xiaodan Fan, Mark Gerstein, Alfred S L Cheng, Kevin Y Yip
Nature Genetics   ·   04 Sep 2017   ·   doi:10.1038/ng.3950
TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis
Y Zhou, T Huang, J Zhang, C C Wong, B Zhang, ..., W K K Wu, A S L Cheng, J Yu, W Kang, K F To
Oncogene   ·   31 Jul 2017   ·   doi:10.1038/onc.2017.257
IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis
Yuhang Zhou, Tingting Huang, Ho Lam Siu, Chi Chun Wong, Yujuan Dong, ..., William K. K. Wu, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Molecular Cancer   ·   11 Apr 2017   ·   doi:10.1186/s12943-017-0647-2
The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP–PKA–EGFR–STAT3 axis
M Zhou, M T S Mok, H Sun, A W Chan, Y Huang, A S L Cheng, G Xu
Oncogene   ·   20 Mar 2017   ·   doi:10.1038/onc.2017.38
The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis
Li Zhang, Yuhang Zhou, Tingting Huang, Alfred Cheng, Jun Yu, Wei Kang, Ka To
International Journal of Molecular Sciences   ·   20 Feb 2017   ·   doi:10.3390/ijms18020450
Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification
William K.K. Wu, Xiangchun Li, Xiansong Wang, Rudin Z.W. Dai, Alfred S.L. Cheng, ..., Thomas Kwong, Tai C. Chow, Jun Yu, Matthew T.V. Chan, Sunny H. Wong
Molecular Biology and Evolution   ·   12 Jan 2017   ·   doi:10.1093/molbev/msw295

2016

NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?
Tingting Huang, Yuhang Zhou, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Molecular Cancer   ·   01 Dec 2016   ·   doi:10.1186/s12943-016-0566-7
A transcriptional-microRNA network for β-catenin-driven stemness in hepatocellular carcinoma
William K. K. Wu, Matthew T. V. Chan, Alfred S. L. Cheng
Translational Cancer Research   ·   01 Dec 2016   ·   doi:10.21037/tcr.2016.12.34
Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy
Man Liu, Jingying Zhou, Zhiwei Chen, Alfred Sze‐Lok Cheng
The Journal of Pathology   ·   29 Nov 2016   ·   doi:10.1002/path.4832
Gender Differences in Adipocyte Metabolism and Liver Cancer Progression
Otto K.-W. Cheung, Alfred S.-L. Cheng
Frontiers in Genetics   ·   20 Sep 2016   ·   doi:10.3389/fgene.2016.00168
EZH2 coupled with HOTAIR to silence MicroRNA‐34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma
Chi‐Han Li, Zhangang Xiao, Joanna Hung–Man Tong, Ka‐Fai To, Xiangdong Fang, Alfred SL Cheng, Yangchao Chen
International Journal of Cancer   ·   19 Sep 2016   ·   doi:10.1002/ijc.30414
Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis
Yuan Tian, Myth Mok, Pengyuan Yang, Alfred Cheng
Cancers   ·   20 Aug 2016   ·   doi:10.3390/cancers8080076
Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer
Chung-Min Yeh, Liang-Yu Chang, Shu-Hui Lin, Jian-Liang Chou, Hsiao-Yen Hsieh, ..., Alfred S. L. Cheng, Shu-Fen Wu, Jiayuh Lin, Kun-Tu Yeh, Michael W. Y. Chan
Scientific Reports   ·   16 Aug 2016   ·   doi:10.1038/srep31690
Combinatorial epigenetic deregulation by Helicobacter pylori and Epstein-Barr virus infections in gastric tumourigenesis
William KK Wu, Jun Yu, Matthew TV Chan, Ka F To, Alfred SL Cheng
The Journal of Pathology   ·   20 May 2016   ·   doi:10.1002/path.4731
C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties
Kai-Yu Ng, Stella Chai, Man Tong, Xin-Yuan Guan, Chi-Ho Lin, Yick-Pang Ching, Dan Xie, Alfred Sze-Lok Cheng, Stephanie Ma
Oncotarget   ·   19 Mar 2016   ·   doi:10.18632/oncotarget.8209
Yin Yang 1‐mediated epigenetic silencing of tumour‐suppressive microRNAs activates nuclear factor‐κB in hepatocellular carcinoma
Daisy PF Tsang, William KK Wu, Wei Kang, Ying‐Ying Lee, Feng Wu, ..., Jun Yu, Nathalie Wong, Kevin Y Yip, Ka‐Fai To, Alfred SL Cheng
The Journal of Pathology   ·   17 Mar 2016   ·   doi:10.1002/path.4688
A novel role of hepatic epithelial transforming growth factor-β signaling in cholangiocarcinogenesis
Man Liu, Myth T. S. Mok, Alfred S. L. Cheng
Annals of Translational Medicine   ·   01 Mar 2016   ·   doi:10.21037/atm.2016.03.01
miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis
Tingting Huang, Wei Kang, Bin Zhang, Feng Wu, Yujuan Dong, ..., Yuhang Zhou, Li Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To
Molecular Cancer   ·   22 Jan 2016   ·   doi:10.1186/s12943-016-0493-7
Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10
Alfa H. C. Bai, William K. K. Wu, Liangliang Xu, Sunny H. Wong, Minnie Y. Go, ..., Francis K. L. Chan, Joseph J. Y. Sung, Jun Yu, Alfred S. L. Cheng, Siew C. Ng
Journal of Crohn's and Colitis   ·   22 Jan 2016   ·   doi:10.1093/ecco-jcc/jjw020
The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis
Yuhang Zhou, Tingting Huang, Alfred Cheng, Jun Yu, Wei Kang, Ka To
International Journal of Molecular Sciences   ·   21 Jan 2016   ·   doi:10.3390/ijms17010138
Emerging role of Hippo pathway in gastric and other gastrointestinal cancers
Wei Kang
World Journal of Gastroenterology   ·   01 Jan 2016   ·   doi:10.3748/wjg.v22.i3.1279

2015

The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers
Tingting Huang, Wei Kang, Alfred S. L. Cheng, Jun Yu, Ka Fai To
BMC Cancer   ·   01 Dec 2015   ·   doi:10.1186/s12885-015-1984-4
Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Yuan Tian, Vincent W.S. Wong, Grace L.H. Wong, Weiqin Yang, Hanyong Sun, ..., Tim H.M. Huang, Jun Yu, Ka F. To, Alfred S.L. Cheng, Henry L.Y. Chan
Cancer Research   ·   15 Nov 2015   ·   doi:10.1158/0008-5472.CAN-14-3786
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
Jun Yu, Qiang Feng, Sunny Hei Wong, Dongya Zhang, Qiao yi Liang, ..., Nils Brünner, Karsten Kristiansen, Manimozhiyan Arumugam, Joseph Jao-Yiu Sung, Jun Wang
Gut   ·   25 Sep 2015   ·   doi:10.1136/gutjnl-2015-309800
Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development
W Yang, M T S Mok, M S M Li, W Kang, H Wang, ..., J Yu, M W Y Chan, F K L Chan, J J Y Sung, A S L Cheng
Oncogene   ·   27 Jul 2015   ·   doi:10.1038/onc.2015.276
Correction: FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells
Shun X. Ren, Jin Shen, Alfred S. L. Cheng, Lan Lu, Ruby L. Y. Chan, ..., Francis K. L. Chan, Jun Yu, Joseph J. Y. Sung, William K. K. Wu, Chi H. Cho
PLOS ONE   ·   25 Jun 2015   ·   doi:10.1371/journal.pone.0131750
Autophagy Mediates HBx‐Induced Nuclear Factor‐κB Activation and Release of IL‐6, IL‐8, and CXCL2 in Hepatocytes
Millore X.M. Luo, Sunny H. Wong, Matthew T.V. Chan, Le Yu, Sidney S.B. Yu, ..., Francis K.L. Chan, Chi H. Cho, Jun Yu, Joseph J.Y. Sung, William K.K. Wu
Journal of Cellular Physiology   ·   23 Jun 2015   ·   doi:10.1002/jcp.24967
Truncated HBx‐dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53‐mediated apoptosis
Ranxu Zhu, Myth TS Mok, Wei Kang, Suki SK Lau, Wing‐Kit Yip, ..., Vincent WS Wong, Ka‐Fai To, Joseph JY Sung, Alfred SL Cheng, Henry LY Chan
The Journal of Pathology   ·   28 May 2015   ·   doi:10.1002/path.4554
A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients
Hai Feng, Zhuo Yu, Yuan Tian, Ying-Ying Lee, May S. Li, ..., Andrew M.L. Chan, Ka-Fai To, Henry L.Y. Chan, Joseph J.Y. Sung, Alfred S.L. Cheng
Journal of Hepatology   ·   01 May 2015   ·   doi:10.1016/j.jhep.2014.11.040
CUL4B: a novel epigenetic driver in Wnt/β‐catenin‐dependent hepatocarcinogenesis
Myth T.S. Mok, Alfred S.L. Cheng
The Journal of Pathology   ·   03 Mar 2015   ·   doi:10.1002/path.4512
Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma
Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Junhong Zhao, ..., Weiqin Yang, Jesse CS Pang, Alfred SL Cheng, Jun Yu, Ka Fai To
Molecular Cancer   ·   22 Feb 2015   ·   doi:10.1186/s12943-015-0323-3
Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote Helicobacter pylori–Induced Gastric Carcinogenesis
Jing Shen, Zhangang Xiao, William K.K. Wu, Maggie H. Wang, Ka F. To, ..., Matthew T.V. Chan, Francis K.L. Chan, Joseph J.Y. Sung, Alfred S.L. Cheng, Chi H. Cho
Cancer Research   ·   15 Feb 2015   ·   doi:10.1158/0008-5472.CAN-14-1301
Rectifying the Epigenetic Field Defect in Gastric Carcinogenesis
[no author info]
Journal of Cancer Sciences   ·   01 Jan 2015   ·   doi:10.13188/2377-9292.1000010
Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial–mesenchymal transition
Bin Zhang, Yan Yang, Xiaoting Shi, Wanyu Liao, Min Chen, ..., Tingsheng Ling, Xiaoqi Zhang, Lei Wang, Yuzheng Zhuge, Xiaoping Zou
Cancer Letters   ·   01 Jan 2015   ·   doi:10.1016/j.canlet.2014.10.016

2014

The ubiquitin ligases RNF8 and RNF168 display rapid but distinct dynamics at DNA repair foci in living cells
Myth T.S. Mok, Alfred S.L. Cheng, Beric R. Henderson
The International Journal of Biochemistry & Cell Biology   ·   01 Dec 2014   ·   doi:10.1016/j.biocel.2014.09.027
let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis
Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Weiqin Yang, Yi Pan, Kin Mang Lau, Jun Yu, Alfred SL Cheng, Ka Fai To
Journal of Translational Medicine   ·   05 Oct 2014   ·   doi:10.1186/s12967-014-0281-3
Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer
Junhong Zhao, Yujuan Dong, Wei Kang, Minnie Y. Go, Joanna HM. Tong, ..., Philip WY. Chiu, Alfred SL. Cheng, Ka Fai To, Joseph JY. Sung, Jun Yu
Oncoscience   ·   03 Jul 2014   ·   doi:10.18632/oncoscience.62
The Janus Face of Cathelicidin in Tumorigenesis
W.K.K. Wu, J.J.Y. Sung, A.S.L. Cheng, F.K.L. Chan, S.S.M. Ng, ..., X.J. Wang, L. Zhang, S.H. Wong, J. Yu, C.H. Cho
Current Medicinal Chemistry   ·   11 May 2014   ·   doi:10.2174/0929867321666140205135351
Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma
WEI KANG, JOANNA H.M. TONG, ANTHONY W.H. CHAN, JUNHONG ZHAO, SHIYAN WANG, ..., FRANKIE M.C. SIN, SAIFUNG YEUNG, ALFRED S.L. CHENG, JUN YU, KAFAI TO
Oncology Reports   ·   23 Apr 2014   ·   doi:10.3892/or.2014.3148
Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma
Wei Kang, Joanna HM Tong, Anthony WH Chan, Junhong Zhao, Yujuan Dong, ..., Frankie MC Sin, Simon SM Ng, Jun Yu, Alfred SL Cheng, Ka Fai To
Journal of Translational Medicine   ·   28 Mar 2014   ·   doi:10.1186/1479-5876-12-80
MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function
WEI KANG, JOANNA H.M. TONG, ANTHONY W.H. CHAN, ALFRED S.L. CHENG, JUN YU, KAFAI TO
Oncology Reports   ·   19 Mar 2014   ·   doi:10.3892/or.2014.3094
Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis
Zhuo Yu, Yue-Qiu Gao, Hai Feng, Ying-Ying Lee, May S Li, ..., Jun Yu, Vincent W S Wong, Joseph J Y Sung, Henry L Y Chan, Alfred S L Cheng
Gut   ·   17 Jan 2014   ·   doi:10.1136/gutjnl-2013-305584
Depletion of Sirtuin 1 (SIRT1) Leads to Epigenetic Modifications of Telomerase (TERT) Gene in Hepatocellular Carcinoma Cells
Bin Zhang, Juan Chen, Alfred S. L. Cheng, Ben C. B. Ko
PLoS ONE   ·   08 Jan 2014   ·   doi:10.1371/journal.pone.0084931

2013

Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease
Yuan Tian, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan, Alfred Sze-Lok Cheng
Seminars in Cancer Biology   ·   01 Dec 2013   ·   doi:10.1016/j.semcancer.2013.08.010
A novel crosstalk between two major protein degradation systems
Xiao J Wang, Jun Yu, Sunny H Wong, Alfred SL Cheng, Francis KL Chan, Simon SM Ng, Chi H Cho, Joseph JY Sung, William KK Wu
Autophagy   ·   25 Oct 2013   ·   doi:10.4161/auto.25573
Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
William K.K. Wu, Xiao J. Wang, Alfred S.L. Cheng, Millore X.M. Luo, Simon S.M. Ng, Ka F. To, Francis K.L. Chan, Chi H. Cho, Joseph J.Y. Sung, Jun Yu
Critical Reviews in Oncology/Hematology   ·   01 Jun 2013   ·   doi:10.1016/j.critrevonc.2012.11.009
FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells
Shun X. Ren, Jin Shen, Alfred S. L. Cheng, Lan Lu, Ruby L. Y. Chan, ..., Francis K. L. Chan, Jun Yu, Joseph J. Y. Sung, William K. K. Wu, Chi H. Cho
PLoS ONE   ·   20 May 2013   ·   doi:10.1371/journal.pone.0063641
Alliance of epigenetic forces for the activation of oncogenic Wnt/β‐catenin signaling
Alfa HC Bai, Alfred SL Cheng
Journal of Gastroenterology and Hepatology   ·   26 Feb 2013   ·   doi:10.1111/jgh.12090
Full‐length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells
Yuen-Keng Ng, Wing-Sze Lau, Vivian Wai Yan Lui, Alfred Sze-Lok Cheng, Patrick Kwok-Shing Ng, Stephen Kwok-Wing Tsui, Yue Sun Cheung, Paul Bo San Lai
FEBS Letters   ·   21 Jan 2013   ·   doi:10.1016/j.febslet.2013.01.018
Helicobacter pylori Causes Epigenetic Dysregulation of FOXD3 to Promote Gastric Carcinogenesis
Alfred S.L. Cheng, May S. Li, Wei Kang, Victoria Y. Cheng, Jian–Liang Chou, ..., Tim H. Huang, Ka F. To, Michael W. Chan, Joseph J.Y. Sung, Francis K.L. Chan
Gastroenterology   ·   01 Jan 2013   ·   doi:10.1053/j.gastro.2012.10.002

2012

Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice
L Zhang, J Yu, C C M Wong, T K W Ling, Z J Li, ..., K F To, R L Gallo, J J Y Sung, W K K Wu, C H Cho
Gene Therapy   ·   20 Dec 2012   ·   doi:10.1038/gt.2012.92
Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer
Shun X. Ren, Alfred S.L. Cheng, Ka F. To, Joanna H.M. Tong, May S. Li, ..., Francis K.L. Chan, Jun Yu, Joseph J.Y. Sung, William K.K. Wu, Chi H. Cho
Cancer Research   ·   15 Dec 2012   ·   doi:10.1158/0008-5472.CAN-12-2359
Epigenetic Deregulation of MicroRNAs: New Opportunities to Target Oncogenic Signaling Pathways in Hepatocellular Carcinoma
Zhuo Yu, Alfred Sze-Lok Cheng
Current Pharmaceutical Design   ·   10 Dec 2012   ·   doi:10.2174/138161213804805757
CITED2 is a novel direct effector of peroxisome proliferator‐activated receptor γ in suppressing hepatocellular carcinoma cell growth
Kin‐Fai Cheung, Junhong Zhao, Ying Hao, Xiaoxing Li, Anson W. Lowe, Alfred S. L. Cheng, Joseph J. Y. Sung, Jun Yu
Cancer   ·   04 Dec 2012   ·   doi:10.1002/cncr.27865
Epigenetic Deregulation of MicroRNAs: New Opportunities to Target Oncogenic Signaling Pathways in Hepatocellular Carcinoma
Zhuo Yu, Alfred Sze-Lok Cheng
Current Pharmaceutical Design   ·   01 Dec 2012   ·   doi:10.2174/1381612811319070003
Hydrogen Sulfide Lowers Proliferation and Induces Protective Autophagy in Colon Epithelial Cells
Ya C. Wu, Xiao J. Wang, Le Yu, Francis K. L. Chan, Alfred S. L. Cheng, Jun Yu, Joseph J. Y. Sung, William K. K. Wu, Chi H. Cho
PLoS ONE   ·   29 May 2012   ·   doi:10.1371/journal.pone.0037572
Stathmin1 Plays Oncogenic Role and Is a Target of MicroRNA-223 in Gastric Cancer
Wei Kang, Joanna H. M. Tong, Anthony W. H. Chan, Raymond W. M. Lung, Shuk Ling Chau, Queenie W. L. Wong, Nathalie Wong, Jun Yu, Alfred S. L. Cheng, Ka Fai To
PLoS ONE   ·   28 Mar 2012   ·   doi:10.1371/journal.pone.0033919
Viral Associated Hepatocellular Carcinoma
[no author info]
Molecular Aspects of Hepatocellular Carcinoma   ·   11 Mar 2012   ·   doi:10.2174/978160805072711201010021
Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma
Kin-Mang Lau, Queeny Kwan Yi Chan, Jesse C. S. Pang, Fanny Man-Ting Ma, Kay K. W. Li, ..., Hiu-Ming Li, Liangfu Zhou, Yin Wang, Ying Mao, Ho-Keung Ng
Acta Neuropathologica   ·   17 Jan 2012   ·   doi:10.1007/s00401-011-0934-8

2011

Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients
X Li, K F Cheung, X Ma, L Tian, J Zhao, ..., J Ying, Q Tao, J J Y Sung, H-f Kung, J Yu
Oncogene   ·   21 Nov 2011   ·   doi:10.1038/onc.2011.511
Carboxyl-Terminal Truncated HBx Regulates a Distinct MicroRNA Transcription Program in Hepatocellular Carcinoma Development
Wing-Kit Yip, Alfred Sze-Lok Cheng, Ranxu Zhu, Raymond Wai-Ming Lung, Daisy Pui-Fong Tsang, ..., Nathalie Wong, Ka-Fai To, Vincent Wai-Sun Wong, Joseph Jao-Yiu Sung, Henry Lik-Yuen Chan
PLoS ONE   ·   04 Aug 2011   ·   doi:10.1371/journal.pone.0022888
Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β-catenin/T cell factor–dependent hepatocarcinogenesis
Hai Feng, Alfred S.L. Cheng, Daisy P. Tsang, May S. Li, Minnie Y. Go, ..., Marie C. Lin, Jun Yu, Paul B. Lai, Ka F. To, Joseph J.Y. Sung
Journal of Clinical Investigation   ·   01 Aug 2011   ·   doi:10.1172/JCI45967
Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer
Kin‐Fai Cheung, Cleo N. Y. Lam, Kaichun Wu, Enders K. O. Ng, Wilson W. S. Chong, Alfred S. L. Cheng, Ka‐Fai To, Daiming Fan, Joseph J. Y. Sung, Jun Yu
Cancer   ·   29 Jun 2011   ·   doi:10.1002/cncr.26189
EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis
Alfred S.L. Cheng, Suki S. Lau, Yangchao Chen, Yutaka Kondo, May S. Li, ..., Jun Yu, Ka F. To, Nathalie Wong, Tim H.-M. Huang, Joseph J.Y. Sung
Cancer Research   ·   31 May 2011   ·   doi:10.1158/0008-5472.CAN-10-3342
Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer
Tao Zuo, Ta-Ming Liu, Xun Lan, Yu-I Weng, Rulong Shen, ..., Charles L. Shapiro, Huey-Jen L. Lin, Alfred S. L. Cheng, Victor X. Jin, Tim H.-M. Huang
Cancer Research   ·   01 Mar 2011   ·   doi:10.1158/0008-5472.CAN-10-3573

2010

Epigenetic regulation of signaling pathways in cancer: Role of the histone methyltransferase EZH2
Daisy PF Tsang, Alfred SL Cheng
Journal of Gastroenterology and Hepatology   ·   22 Dec 2010   ·   doi:10.1111/j.1440-1746.2010.06447.x
NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors
Vivian Y. Shin, Hongchuan Jin, Enders K.O. Ng, Alfred S.L. Cheng, Wilson W.S. Chong, Christine Y.P. Wong, Wai K. Leung, Joseph J.Y. Sung, Kent-Man Chu
Carcinogenesis   ·   15 Nov 2010   ·   doi:10.1093/carcin/bgq240
TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy
Swarnali Acharyya, Sudarshana M. Sharma, Alfred S. Cheng, Katherine J. Ladner, Wei He, William Kline, Huating Wang, Michael C. Ostrowski, Tim H. Huang, Denis C. Guttridge
PLoS ONE   ·   30 Aug 2010   ·   doi:10.1371/journal.pone.0012479
PPARγ is essential for protection against nonalcoholic steatohepatitis
C W Wu, E S H Chu, C N Y Lam, A S L Cheng, C W Lee, V W S Wong, J J Y Sung, J Yu
Gene Therapy   ·   08 Apr 2010   ·   doi:10.1038/gt.2010.41
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro
Jun Yu, Bo Shen, Eagle S. H. Chu, Narci Teoh, Kin-Fai Cheung, ..., Junhong Zhao, Alfred S. L. Cheng, Ka-Fai To, Henry L. Y. Chan, Joseph J. Y. Sung
Hepatology   ·   28 Jan 2010   ·   doi:10.1002/hep.23550
Interaction of Adipokines and Hepatitis B Virus on Histological Liver Injury in the Chinese
Vincent Wai-Sun Wong, Grace Lai-Hung Wong, Jun Yu, Paul Cheung-Lung Choi, Anthony Wing-Hung Chan, ..., Alfred Sze-Lok Cheng, Angel Mei-Ling Chim, Francis Ka-Leung Chan, Joseph Jao-Yiu Sung, Henry Lik-Yuen Chan
American Journal of Gastroenterology   ·   01 Jan 2010   ·   doi:10.1038/ajg.2009.560

2009

Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis
X Liu, X Wang, J Zhang, E K Y Lam, V Y Shin, A S L Cheng, J Yu, F K L Chan, J J Y Sung, H C Jin
Oncogene   ·   02 Nov 2009   ·   doi:10.1038/onc.2009.332
An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules
Huaxia Qin, Michael WY Chan, Sandya Liyanarachchi, Curtis Balch, Dustin Potter, ..., Kenneth P Nephew, Joel H Saltz, Louise C Showe, Tim HM Huang, Ramana V Davuluri
BMC Systems Biology   ·   17 Jul 2009   ·   doi:10.1186/1752-0509-3-73
Xenoestrogen-Induced Epigenetic Repression of microRNA-9-3 in Breast Epithelial Cells
Pei-Yin Hsu, Daniel E. Deatherage, Benjamin A.T. Rodriguez, Sandya Liyanarachchi, Yu-I Weng, Tao Zuo, Joseph Liu, Alfred S.L. Cheng, Tim H-M. Huang
Cancer Research   ·   15 Jul 2009   ·   doi:10.1158/0008-5472.CAN-08-4914
High serum interleukin‐6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
Vincent Wai‐Sun Wong, Jun Yu, Alfred Sze‐Lok Cheng, Grace Lai‐Hung Wong, Hoi‐Yun Chan, Eagle Siu‐Hong Chu, Enders Kai‐On Ng, Francis Ka‐Leung Chan, Joseph Jao‐Yao Sung, Henry Lik‐Yuen Chan
International Journal of Cancer   ·   06 Mar 2009   ·   doi:10.1002/ijc.24281

2008

NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma
Huating Wang, Ramiro Garzon, Hao Sun, Katherine J. Ladner, Ravi Singh, ..., Brett M. Hall, Stephen J. Qualman, Dawn S. Chandler, Carlo M. Croce, Denis C. Guttridge
Cancer Cell   ·   01 Nov 2008   ·   doi:10.1016/j.ccr.2008.10.006
COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis
Alfred S.L. Cheng, Jun Yu, Paul B.S. Lai, Henry L.Y. Chan, Joseph J.Y. Sung
Biochemical and Biophysical Research Communications   ·   01 Sep 2008   ·   doi:10.1016/j.bbrc.2008.06.098
Aberrant Transforming Growth Factor β1 Signaling and SMAD4 Nuclear Translocation Confer Epigenetic Repression of ADAM19 in Ovarian Cancer
Michael W.Y. Chan, Yi-Wen Huang, Corinna Hartman-Frey, Chieh-Ti Kuo, Daniel Deatherage, ..., Pearlly S. Yan, Ramana V. Davuluri, Tim H.-M. Huang, Kenneth P. Nephew, Huey-Jen L. Lin
Neoplasia   ·   01 Sep 2008   ·   doi:10.1593/neo.08540
Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice
Jun Yu, Chung W. Wu, Eagle S.H. Chu, Alex Y. Hui, Alfred S.L. Cheng, Minnie Y.Y. Go, Arthur K.K. Ching, Yiu L. Chui, Henry L.Y. Chan, Joseph J.Y. Sung
Biochemical and Biophysical Research Communications   ·   01 Aug 2008   ·   doi:10.1016/j.bbrc.2008.05.069
Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice
Wai K. Leung, Kai-chun Wu, Christine Y. P. Wong, Alfred S. L. Cheng, Arthur K. K. Ching, ..., Ka-Fai To, Xin Wang, Y. L. Chui, D. M. Fan, Joseph J. Y. Sung
Carcinogenesis   ·   07 Jul 2008   ·   doi:10.1093/carcin/bgn156
Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
Benjamin A.T. Rodriguez, Alfred S.L. Cheng, Pearlly S. Yan, Dustin Potter, Francisco J. Agosto-Perez, Charles L. Shapiro, Tim H.-M. Huang
Carcinogenesis   ·   21 May 2008   ·   doi:10.1093/carcin/bgn115
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Yutaka Kondo, Lanlan Shen, Alfred S Cheng, Saira Ahmed, Yanis Boumber, ..., Bernard Kwabi-Addo, David L Gold, Yoshitaka Sekido, Tim Hui-Ming Huang, Jean-Pierre J Issa
Nature Genetics   ·   18 May 2008   ·   doi:10.1038/ng.159
Epithelial Progeny of Estrogen-Exposed Breast Progenitor Cells Display a Cancer-like Methylome
Alfred S.L. Cheng, Aedín C. Culhane, Michael W.Y. Chan, Chinnambally R. Venkataramu, Mathias Ehrich, ..., Pearlly S. Yan, John Quackenbush, Kenneth P. Nephew, Timothy J. Yeatman, Tim H-M. Huang
Cancer Research   ·   13 Mar 2008   ·   doi:10.1158/0008-5472.CAN-07-5547

2007

Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells
Michael Chan, Christine Wong, Alfred Cheng, Victor Chan, Ka Chan, Ka To, Francis Chan, Joseph Sung, Wai Leung
Oncology Reports   ·   01 Dec 2007   ·   doi:10.3892/or.18.6.1557
RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma
Alfred S.L. Cheng, Nathalie Wong, Ada M.Y. Tse, Kathy Y.Y. Chan, Kai K. Chan, Joseph J.Y. Sung, Henry L.Y. Chan
Cancer Letters   ·   01 Aug 2007   ·   doi:10.1016/j.canlet.2007.01.004
Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis
J. Yu, A. Y Hui, E. S H Chu, A. S L Cheng, M. Y Y Go, ..., K. F Cheung, A. K K Ching, Y. L Chui, K. K Chan, J. J Y Sung
Gut   ·   01 Jul 2007   ·   doi:10.1136/gut.2006.097923
Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-κB in adult T-cell leukemia/lymphoma
M V P Nadella, W P Dirksen, K S Nadella, S Shu, A S Cheng, ..., V Richard, S A Fernandez, T H Huang, D Guttridge, T J Rosol
Leukemia   ·   07 Jun 2007   ·   doi:10.1038/sj.leu.2404798

2006

Diverse Gene Expression and DNA Methylation Profiles Correlate with Differential Adaptation of Breast Cancer Cells to the Antiestrogens Tamoxifen and Fulvestrant
Meiyun Fan, Pearlly S. Yan, Cori Hartman-Frey, Lei Chen, Henry Paik, ..., Alfred S.L. Cheng, Lang Li, Phillip H. Abbosh, Tim H-M. Huang, Kenneth P. Nephew
Cancer Research   ·   15 Dec 2006   ·   doi:10.1158/0008-5472.CAN-06-1666
A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-α
Lang Li, Alfred S. L. Cheng, Victor X. Jin, Henry H. Paik, Meiyun Fan, ..., Curtis Balch, Ramana V. Davuluri, Sun Kim, Tim H.-M. Huang, Kenneth P. Nephew
Bioinformatics   ·   29 Jun 2006   ·   doi:10.1093/bioinformatics/btl329
Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters
Alfred S.L. Cheng, Victor X. Jin, Meiyun Fan, Laura T. Smith, Sandya Liyanarachchi, ..., Michael W.Y. Chan, Christoph Plass, Kenneth P. Nephew, Ramana V. Davuluri, Tim H.-M. Huang
Molecular Cell   ·   01 Feb 2006   ·   doi:10.1016/j.molcel.2005.12.016

2004

Effect of prostaglandin E2 and prostaglandin I2 on PDGF-induced proliferation of LI90, a human hepatic stellate cell line
Alex Yui Hui, Alfred Sze-Lok Cheng, Henry Lik-Yuen Chan, Minnie Yin-Yin Go, Francis Ka-Leung Chan, Ryuichiro Sakata, Takato Ueno, Michio Sata, Joseph Jao-Yiu Sung
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)   ·   01 Nov 2004   ·   doi:10.1016/j.plefa.2004.04.007
Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2
Alfred S-L Cheng, Henry L-Y Chan, Wai K Leung, Ka F To, Minnie Y-Y Go, John Y-H Chan, Choong T Liew, Joseph J-Y Sung
Modern Pathology   ·   01 Oct 2004   ·   doi:10.1038/modpathol.3800196
Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma
Alfred Cheng, Henry Chan, Ka To, Wai Leung, Ka Chan, Choong Liew, Joseph Sung
International Journal of Oncology   ·   01 Apr 2004   ·   doi:10.3892/ijo.24.4.853

2003

Bioengineering and Characterization of Physeal Transplant with Physeal Reconstruction Potential
Kwong Man Lee, Alfred Sze Lok Cheng, Wing Hoi Cheung, Pauline Po Yee Lui, Vincent Ooi, Kwok Pui Fung, Ping Chung Leung, Kwok Sui Leung
Tissue Engineering   ·   01 Aug 2003   ·   doi:10.1089/107632703768247395
Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells
Alfred Cheng, Henry Chan, Wai Leung, Nathalie Wong, Philip Johnson, Joseph Sung
International Journal of Oncology   ·   01 Jul 2003   ·   doi:10.3892/ijo.23.1.113

2002

Expression of cyclooxygenase‐2 in chronic hepatitis B and the effects of anti‐viral therapy
A. S. L. Cheng, H. L. Y. Chan, N. W. Y. Leung, C. T. Liew, K. F. To, P. B. S. Lai, J. J. Y. Sung
Alimentary Pharmacology & Therapeutics   ·   18 Jan 2002   ·   doi:10.1046/j.1365-2036.2002.01163.x

2001

Expression and cellular localization of COX‐1 and ‐2 in Helicobacter pylori gastritis
F. K. L. Chan, K. F. To, Y. P. Ng, T. L. Lee, A. S. L. Cheng, W. K. Leung, J. J. Y. Sung
Alimentary Pharmacology & Therapeutics   ·   05 Feb 2001   ·   doi:10.1046/j.1365-2036.2001.00918.x
Up‐regulation of cyclooxygenase‐1 and ‐2 in human gastric ulcer
K. F. To, F. K. L. Chan, A. S. L. Cheng, T. L. Lee, Y. P. Ng, J. J. Y. Sung
Alimentary Pharmacology & Therapeutics   ·   17 Jan 2001   ·   doi:10.1046/j.1365-2036.2001.00889.x

2000

Cyclooxygenase-2 Expression in Helicobacter pylori-Associated Premalignant and Malignant Gastric Lesions
Joseph J.Y. Sung, Wai K. Leung, Minnie Y.Y. Go, Ka F. To, Alfred S.L. Cheng, Enders K.W. Ng, Francis K.L. Chan
The American Journal of Pathology   ·   01 Sep 2000   ·   doi:10.1016/S0002-9440(10)64586-5