Publications
Highlights
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Gut
·
05 Apr 2023
·
doi:10.1136/gutjnl-2022-328364
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Molecular Therapy
·
04 Jan 2023
·
doi:10.1016/j.ymthe.2022.09.012
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
Cellular & Molecular Immunology
·
20 May 2022
·
doi:10.1038/s41423-022-00872-3
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
Science Translational Medicine
·
07 Apr 2021
·
doi:10.1126/scitranslmed.aaz6804
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis
Cellular & Molecular Immunology
·
02 Sep 2020
·
doi:10.1038/s41423-020-00534-2
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
Gut
·
07 Jan 2020
·
doi:10.1136/gutjnl-2018-317257
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Nature Communications
·
29 Jul 2019
·
doi:10.1038/s41467-019-11274-x
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Nature Communications
·
18 Jan 2019
·
doi:10.1038/s41467-018-08245-z
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
Nature Communications
·
06 Dec 2018
·
doi:10.1038/s41467-018-07402-8
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
Gut
·
22 Sep 2017
·
doi:10.1136/gutjnl-2017-314032
All Publications
2023
Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis
iScience
·
01 Oct 2023
·
doi:10.1016/j.isci.2023.107626
The E2F1–HOXB9 /PBX2–CDK6 axis drives gastric tumorigenesis and serves as a therapeutic target in gastric cancer
The Journal of Pathology
·
05 Jun 2023
·
doi:10.1002/path.6091
Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models
Scientific Reports
·
25 Apr 2023
·
doi:10.1038/s41598-023-33869-7
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Gut
·
05 Apr 2023
·
doi:10.1136/gutjnl-2022-328364
Compromised browning in white adipose tissue of ageing people
European Journal of Endocrinology
·
08 Feb 2023
·
doi:10.1093/ejendo/lvad014
Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma
Molecular Therapy
·
04 Jan 2023
·
doi:10.1016/j.ymthe.2022.09.012
Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing
Research
·
01 Jan 2023
·
doi:10.34133/research.0182
2022
Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2 –IGF1R and Hippo–YAP1 signaling pathways
The Journal of Pathology
·
17 Dec 2022
·
doi:10.1002/path.6033
Meltdown of the cold tumour microenvironment: a new ‘translational’ approach to augment immunotherapy efficacy
Gut
·
13 Dec 2022
·
doi:10.1136/gutjnl-2022-328861
Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties
Journal of Medicinal Chemistry
·
30 Nov 2022
·
doi:10.1021/acs.jmedchem.2c01132
Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients
Gut
·
30 Nov 2022
·
doi:10.1136/gutjnl-2022-327133
The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma
Cancer Letters
·
01 Nov 2022
·
doi:10.1016/j.canlet.2022.215914
Eliminating METTL1‐mediated accumulation of PMN‐MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation
Hepatology
·
08 Jul 2022
·
doi:10.1002/hep.32585
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
Cellular & Molecular Immunology
·
20 May 2022
·
doi:10.1038/s41423-022-00872-3
Vitamin D3and carbamazepine protect againstClostridioides difficileinfection in mice by restoring macrophage lysosome acidification
Autophagy
·
06 Jan 2022
·
doi:10.1080/15548627.2021.2016004
Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis
Cancer Letters
·
01 Jan 2022
·
doi:10.1016/j.canlet.2021.10.039
MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target
Theranostics
·
01 Jan 2022
·
doi:10.7150/thno.75431
2021
Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition
Advanced Science
·
17 Nov 2021
·
doi:10.1002/advs.202101235
Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives
Cancers
·
17 May 2021
·
doi:10.3390/cancers13102418
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
Science Translational Medicine
·
07 Apr 2021
·
doi:10.1126/scitranslmed.aaz6804
Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade
JHEP Reports
·
01 Apr 2021
·
doi:10.1016/j.jhepr.2020.100224
Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance
Briefings in Bioinformatics
·
30 Mar 2021
·
doi:10.1093/bib/bbab040
A proof-of-concept study for the pathogenetic role of enhancer hypomethylation of MYBPHL in multiple myeloma
Scientific Reports
·
26 Mar 2021
·
doi:10.1038/s41598-021-86473-y
NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway
Oncogene
·
15 Jan 2021
·
doi:10.1038/s41388-020-01579-3
2020
MCM family in gastrointestinal cancer and other malignancies: From functional characterization to clinical implication
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
·
01 Dec 2020
·
doi:10.1016/j.bbcan.2020.188415
The Intersection between Oral Microbiota, Host Gene Methylation and Patient Outcomes in Head and Neck Squamous Cell Carcinoma
Cancers
·
18 Nov 2020
·
doi:10.3390/cancers12113425
FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential
Oncogene
·
15 Sep 2020
·
doi:10.1038/s41388-020-01458-x
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis
Cellular & Molecular Immunology
·
02 Sep 2020
·
doi:10.1038/s41423-020-00534-2
A unified framework for integrative study of heterogeneous gene regulatory mechanisms
Nature Machine Intelligence
·
27 Jul 2020
·
doi:10.1038/s42256-020-0205-2
Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation
Cellular Oncology
·
04 Jul 2020
·
doi:10.1007/s13402-020-00546-0
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis
Oncogene
·
20 Apr 2020
·
doi:10.1038/s41388-020-1293-5
Autism‐associated PTEN missense mutation leads to enhanced nuclear localization and neurite outgrowth in an induced pluripotent stem cell line
The FEBS Journal
·
26 Mar 2020
·
doi:10.1111/febs.15287
Gastric cancer: genome damaged by bugs
Oncogene
·
02 Mar 2020
·
doi:10.1038/s41388-020-1241-4
Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma
Gut
·
07 Jan 2020
·
doi:10.1136/gutjnl-2018-317257
2019
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Nature Communications
·
29 Jul 2019
·
doi:10.1038/s41467-019-11274-x
Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis
Cells
·
25 Jun 2019
·
doi:10.3390/cells8060637
Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis
International Journal of Molecular Sciences
·
29 Mar 2019
·
doi:10.3390/ijms20071576
New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation
Genome Research
·
19 Feb 2019
·
doi:10.1101/gr.240036.118
E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness
Cancer Science
·
25 Jan 2019
·
doi:10.1111/cas.13920
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Nature Communications
·
18 Jan 2019
·
doi:10.1038/s41467-018-08245-z
2018
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
Nature Communications
·
06 Dec 2018
·
doi:10.1038/s41467-018-07402-8
Targeting the miR-630/YAP1/ERK feedback loop in epidermal growth factor receptor-mutated lung adenocarcinomas
Journal of Thoracic Disease
·
01 Nov 2018
·
doi:10.21037/jtd.2018.10.16
Oncogenes expand during evolution to withstand somatic amplification
Annals of Oncology
·
01 Nov 2018
·
doi:10.1093/annonc/mdy397
Androgen receptor drives hepatocellular carcinogenesis by activating enhancer of zeste homolog 2-mediated Wnt/β-catenin signaling
EBioMedicine
·
01 Sep 2018
·
doi:10.1016/j.ebiom.2018.08.043
FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p
Oncogene
·
06 Aug 2018
·
doi:10.1038/s41388-018-0430-x
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis
Nucleic Acids Research
·
10 Jul 2018
·
doi:10.1093/nar/gky589
Emerging roles of Hippo signaling in inflammation and YAP-driven tumor immunity
Cancer Letters
·
01 Jul 2018
·
doi:10.1016/j.canlet.2018.04.004
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Pharmacology & Therapeutics
·
01 Jun 2018
·
doi:10.1016/j.pharmthera.2018.01.008
PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis
Molecular Carcinogenesis
·
02 May 2018
·
doi:10.1002/mc.22831
The physiological role of Motin family and its dysregulation in tumorigenesis
Journal of Translational Medicine
·
12 Apr 2018
·
doi:10.1186/s12967-018-1466-y
Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase
Scientific Reports
·
01 Mar 2018
·
doi:10.1038/s41598-018-22113-2
miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis
Cell Death & Disease
·
24 Jan 2018
·
doi:10.1038/s41419-017-0134-0
2017
SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis
Oncogene
·
13 Dec 2017
·
doi:10.1038/s41388-017-0029-7
The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma
The Journal of Pathology
·
27 Oct 2017
·
doi:10.1002/path.4976
The oncogenic role of Epstein–Barr virus‐encoded microRNA s in Epstein–Barr virus‐associated gastric carcinoma
Journal of Cellular and Molecular Medicine
·
09 Oct 2017
·
doi:10.1111/jcmm.13354
START: a system for flexible analysis of hundreds of genomic signal tracks in few lines of SQL-like queries
BMC Genomics
·
22 Sep 2017
·
doi:10.1186/s12864-017-4071-1
Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy
Gut
·
22 Sep 2017
·
doi:10.1136/gutjnl-2017-314032
Reconstruction of enhancer–target networks in 935 samples of human primary cells, tissues and cell lines
Nature Genetics
·
04 Sep 2017
·
doi:10.1038/ng.3950
TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis
Oncogene
·
31 Jul 2017
·
doi:10.1038/onc.2017.257
IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis
Molecular Cancer
·
11 Apr 2017
·
doi:10.1186/s12943-017-0647-2
The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP–PKA–EGFR–STAT3 axis
Oncogene
·
20 Mar 2017
·
doi:10.1038/onc.2017.38
The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis
International Journal of Molecular Sciences
·
20 Feb 2017
·
doi:10.3390/ijms18020450
Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification
Molecular Biology and Evolution
·
12 Jan 2017
·
doi:10.1093/molbev/msw295
2016
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?
Molecular Cancer
·
01 Dec 2016
·
doi:10.1186/s12943-016-0566-7
A transcriptional-microRNA network for β-catenin-driven stemness in hepatocellular carcinoma
Translational Cancer Research
·
01 Dec 2016
·
doi:10.21037/tcr.2016.12.34
Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy
The Journal of Pathology
·
29 Nov 2016
·
doi:10.1002/path.4832
Gender Differences in Adipocyte Metabolism and Liver Cancer Progression
Frontiers in Genetics
·
20 Sep 2016
·
doi:10.3389/fgene.2016.00168
International Journal of Cancer
·
19 Sep 2016
·
doi:10.1002/ijc.30414
Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis
Cancers
·
20 Aug 2016
·
doi:10.3390/cancers8080076
Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer
Scientific Reports
·
16 Aug 2016
·
doi:10.1038/srep31690
Combinatorial epigenetic deregulation by Helicobacter pylori
and Epstein-Barr virus infections in gastric tumourigenesis
The Journal of Pathology
·
20 May 2016
·
doi:10.1002/path.4731
C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties
Oncotarget
·
19 Mar 2016
·
doi:10.18632/oncotarget.8209
Yin Yang 1‐mediated epigenetic silencing of tumour‐suppressive microRNAs activates nuclear factor‐κB in hepatocellular carcinoma
The Journal of Pathology
·
17 Mar 2016
·
doi:10.1002/path.4688
A novel role of hepatic epithelial transforming growth factor-β signaling in cholangiocarcinogenesis
Annals of Translational Medicine
·
01 Mar 2016
·
doi:10.21037/atm.2016.03.01
miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis
Molecular Cancer
·
22 Jan 2016
·
doi:10.1186/s12943-016-0493-7
Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10
Journal of Crohn's and Colitis
·
22 Jan 2016
·
doi:10.1093/ecco-jcc/jjw020
The TEAD Family and Its Oncogenic Role in Promoting Tumorigenesis
International Journal of Molecular Sciences
·
21 Jan 2016
·
doi:10.3390/ijms17010138
Emerging role of Hippo pathway in gastric and other gastrointestinal cancers
World Journal of Gastroenterology
·
01 Jan 2016
·
doi:10.3748/wjg.v22.i3.1279
2015
The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers
BMC Cancer
·
01 Dec 2015
·
doi:10.1186/s12885-015-1984-4
Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Cancer Research
·
15 Nov 2015
·
doi:10.1158/0008-5472.CAN-14-3786
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
Gut
·
25 Sep 2015
·
doi:10.1136/gutjnl-2015-309800
Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development
Oncogene
·
27 Jul 2015
·
doi:10.1038/onc.2015.276
Correction: FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells
PLOS ONE
·
25 Jun 2015
·
doi:10.1371/journal.pone.0131750
Autophagy Mediates HBx‐Induced Nuclear Factor‐κB Activation and Release of IL‐6, IL‐8, and CXCL2 in Hepatocytes
Journal of Cellular Physiology
·
23 Jun 2015
·
doi:10.1002/jcp.24967
Truncated HBx ‐dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53‐mediated apoptosis
The Journal of Pathology
·
28 May 2015
·
doi:10.1002/path.4554
A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients
Journal of Hepatology
·
01 May 2015
·
doi:10.1016/j.jhep.2014.11.040
The Journal of Pathology
·
03 Mar 2015
·
doi:10.1002/path.4512
Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma
Molecular Cancer
·
22 Feb 2015
·
doi:10.1186/s12943-015-0323-3
Epigenetic Silencing of miR-490-3p Reactivates the Chromatin Remodeler SMARCD1 to Promote Helicobacter pylori–Induced Gastric Carcinogenesis
Cancer Research
·
15 Feb 2015
·
doi:10.1158/0008-5472.CAN-14-1301
Rectifying the Epigenetic Field Defect in Gastric Carcinogenesis
Journal of Cancer Sciences
·
01 Jan 2015
·
doi:10.13188/2377-9292.1000010
Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial–mesenchymal transition
Cancer Letters
·
01 Jan 2015
·
doi:10.1016/j.canlet.2014.10.016
2014
The ubiquitin ligases RNF8 and RNF168 display rapid but distinct dynamics at DNA repair foci in living cells
The International Journal of Biochemistry & Cell Biology
·
01 Dec 2014
·
doi:10.1016/j.biocel.2014.09.027
let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis
Journal of Translational Medicine
·
05 Oct 2014
·
doi:10.1186/s12967-014-0281-3
Helicobacter pylori-induced STAT3 activation and signalling network in gastric cancer
Oncoscience
·
03 Jul 2014
·
doi:10.18632/oncoscience.62
The Janus Face of Cathelicidin in Tumorigenesis
Current Medicinal Chemistry
·
11 May 2014
·
doi:10.2174/0929867321666140205135351
Targeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma
Oncology Reports
·
23 Apr 2014
·
doi:10.3892/or.2014.3148
Dissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma
Hepatobiliary Surgery and Nutrition
·
01 Apr 2014
·
doi:10.3978/j.issn.2304-3881.2014.02.07
Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma
Journal of Translational Medicine
·
28 Mar 2014
·
doi:10.1186/1479-5876-12-80
MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcinoma and siRNA-mediated knockdown suppresses its oncogenic function
Oncology Reports
·
19 Mar 2014
·
doi:10.3892/or.2014.3094
Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis
Gut
·
17 Jan 2014
·
doi:10.1136/gutjnl-2013-305584
Depletion of Sirtuin 1 (SIRT1) Leads to Epigenetic Modifications of Telomerase (TERT) Gene in Hepatocellular Carcinoma Cells
PLoS ONE
·
08 Jan 2014
·
doi:10.1371/journal.pone.0084931
2013
Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease
Seminars in Cancer Biology
·
01 Dec 2013
·
doi:10.1016/j.semcancer.2013.08.010
A novel crosstalk between two major protein degradation systems
Autophagy
·
25 Oct 2013
·
doi:10.4161/auto.25573
Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
Critical Reviews in Oncology/Hematology
·
01 Jun 2013
·
doi:10.1016/j.critrevonc.2012.11.009
FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells
PLoS ONE
·
20 May 2013
·
doi:10.1371/journal.pone.0063641
Alliance of epigenetic forces for the activation of oncogenic W nt/β‐catenin signaling
Journal of Gastroenterology and Hepatology
·
26 Feb 2013
·
doi:10.1111/jgh.12090
Full‐length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells
FEBS Letters
·
21 Jan 2013
·
doi:10.1016/j.febslet.2013.01.018
Helicobacter pylori Causes Epigenetic Dysregulation of FOXD3 to Promote Gastric Carcinogenesis
Gastroenterology
·
01 Jan 2013
·
doi:10.1053/j.gastro.2012.10.002
2012
Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice
Gene Therapy
·
20 Dec 2012
·
doi:10.1038/gt.2012.92
Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer
Cancer Research
·
15 Dec 2012
·
doi:10.1158/0008-5472.CAN-12-2359
Epigenetic Deregulation of MicroRNAs: New Opportunities to Target Oncogenic Signaling Pathways in Hepatocellular Carcinoma
Current Pharmaceutical Design
·
10 Dec 2012
·
doi:10.2174/138161213804805757
CITED2 is a novel direct effector of peroxisome proliferator‐activated receptor γ in suppressing hepatocellular carcinoma cell growth
Cancer
·
04 Dec 2012
·
doi:10.1002/cncr.27865
Epigenetic Deregulation of MicroRNAs: New Opportunities to Target Oncogenic Signaling Pathways in Hepatocellular Carcinoma
Current Pharmaceutical Design
·
01 Dec 2012
·
doi:10.2174/1381612811319070003
Hydrogen Sulfide Lowers Proliferation and Induces Protective Autophagy in Colon Epithelial Cells
PLoS ONE
·
29 May 2012
·
doi:10.1371/journal.pone.0037572
Stathmin1 Plays Oncogenic Role and Is a Target of MicroRNA-223 in Gastric Cancer
PLoS ONE
·
28 Mar 2012
·
doi:10.1371/journal.pone.0033919
Viral Associated Hepatocellular Carcinoma
Molecular Aspects of Hepatocellular Carcinoma
·
11 Mar 2012
·
doi:10.2174/978160805072711201010021
Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma
Acta Neuropathologica
·
17 Jan 2012
·
doi:10.1007/s00401-011-0934-8
2011
Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients
Oncogene
·
21 Nov 2011
·
doi:10.1038/onc.2011.511
Carboxyl-Terminal Truncated HBx Regulates a Distinct MicroRNA Transcription Program in Hepatocellular Carcinoma Development
PLoS ONE
·
04 Aug 2011
·
doi:10.1371/journal.pone.0022888
Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β-catenin/T cell factor–dependent hepatocarcinogenesis
Journal of Clinical Investigation
·
01 Aug 2011
·
doi:10.1172/JCI45967
Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer
Cancer
·
29 Jun 2011
·
doi:10.1002/cncr.26189
EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis
Cancer Research
·
31 May 2011
·
doi:10.1158/0008-5472.CAN-10-3342
Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer
Cancer Research
·
01 Mar 2011
·
doi:10.1158/0008-5472.CAN-10-3573
2010
Epigenetic regulation of signaling pathways in cancer: Role of the histone methyltransferase EZH2
Journal of Gastroenterology and Hepatology
·
22 Dec 2010
·
doi:10.1111/j.1440-1746.2010.06447.x
NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors
Carcinogenesis
·
15 Nov 2010
·
doi:10.1093/carcin/bgq240
TNF Inhibits Notch-1 in Skeletal Muscle Cells by Ezh2 and DNA Methylation Mediated Repression: Implications in Duchenne Muscular Dystrophy
PLoS ONE
·
30 Aug 2010
·
doi:10.1371/journal.pone.0012479
PPARγ is essential for protection against nonalcoholic steatohepatitis
Gene Therapy
·
08 Apr 2010
·
doi:10.1038/gt.2010.41
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro
Hepatology
·
28 Jan 2010
·
doi:10.1002/hep.23550
Interaction of Adipokines and Hepatitis B Virus on Histological Liver Injury in the Chinese
American Journal of Gastroenterology
·
01 Jan 2010
·
doi:10.1038/ajg.2009.560
2009
Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis
Oncogene
·
02 Nov 2009
·
doi:10.1038/onc.2009.332
An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules
BMC Systems Biology
·
17 Jul 2009
·
doi:10.1186/1752-0509-3-73
Xenoestrogen-Induced Epigenetic Repression of microRNA-9-3 in Breast Epithelial Cells
Cancer Research
·
15 Jul 2009
·
doi:10.1158/0008-5472.CAN-08-4914
High serum interleukin‐6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
International Journal of Cancer
·
06 Mar 2009
·
doi:10.1002/ijc.24281
2008
NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma
Cancer Cell
·
01 Nov 2008
·
doi:10.1016/j.ccr.2008.10.006
COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis
Biochemical and Biophysical Research Communications
·
01 Sep 2008
·
doi:10.1016/j.bbrc.2008.06.098
Aberrant Transforming Growth Factor β1 Signaling and SMAD4 Nuclear Translocation Confer Epigenetic Repression of ADAM19 in Ovarian Cancer
Neoplasia
·
01 Sep 2008
·
doi:10.1593/neo.08540
Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice
Biochemical and Biophysical Research Communications
·
01 Aug 2008
·
doi:10.1016/j.bbrc.2008.05.069
Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice
Carcinogenesis
·
07 Jul 2008
·
doi:10.1093/carcin/bgn156
Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer
Carcinogenesis
·
21 May 2008
·
doi:10.1093/carcin/bgn115
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Nature Genetics
·
18 May 2008
·
doi:10.1038/ng.159
Epithelial Progeny of Estrogen-Exposed Breast Progenitor Cells Display a Cancer-like Methylome
Cancer Research
·
13 Mar 2008
·
doi:10.1158/0008-5472.CAN-07-5547
2007
Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells
Oncology Reports
·
01 Dec 2007
·
doi:10.3892/or.18.6.1557
RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma
Cancer Letters
·
01 Aug 2007
·
doi:10.1016/j.canlet.2007.01.004
Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis
Gut
·
01 Jul 2007
·
doi:10.1136/gut.2006.097923
Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-κB in adult T-cell leukemia/lymphoma
Leukemia
·
07 Jun 2007
·
doi:10.1038/sj.leu.2404798
2006
Diverse Gene Expression and DNA Methylation Profiles Correlate with Differential Adaptation of Breast Cancer Cells to the Antiestrogens Tamoxifen and Fulvestrant
Cancer Research
·
15 Dec 2006
·
doi:10.1158/0008-5472.CAN-06-1666
A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-α
Bioinformatics
·
29 Jun 2006
·
doi:10.1093/bioinformatics/btl329
Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters
Molecular Cell
·
01 Feb 2006
·
doi:10.1016/j.molcel.2005.12.016
2004
Effect of prostaglandin E2 and prostaglandin I2 on PDGF-induced proliferation of LI90, a human hepatic stellate cell line
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
·
01 Nov 2004
·
doi:10.1016/j.plefa.2004.04.007
Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2
Modern Pathology
·
01 Oct 2004
·
doi:10.1038/modpathol.3800196
Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma
International Journal of Oncology
·
01 Apr 2004
·
doi:10.3892/ijo.24.4.853
2003
Bioengineering and Characterization of Physeal Transplant with Physeal Reconstruction Potential
Tissue Engineering
·
01 Aug 2003
·
doi:10.1089/107632703768247395
Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells
International Journal of Oncology
·
01 Jul 2003
·
doi:10.3892/ijo.23.1.113
2002
Expression of cyclooxygenase‐2 in chronic hepatitis B and the effects of anti‐viral therapy
Alimentary Pharmacology & Therapeutics
·
18 Jan 2002
·
doi:10.1046/j.1365-2036.2002.01163.x
2001
Expression and cellular localization of COX‐1 and ‐2 in Helicobacter pylori gastritis
Alimentary Pharmacology & Therapeutics
·
05 Feb 2001
·
doi:10.1046/j.1365-2036.2001.00918.x
Up‐regulation of cyclooxygenase‐1 and ‐2 in human gastric ulcer
Alimentary Pharmacology & Therapeutics
·
17 Jan 2001
·
doi:10.1046/j.1365-2036.2001.00889.x
2000
Cyclooxygenase-2 Expression in Helicobacter pylori-Associated Premalignant and Malignant Gastric Lesions
The American Journal of Pathology
·
01 Sep 2000
·
doi:10.1016/S0002-9440(10)64586-5